Palonosetron belongs to a drug class called 5HT3 receptor antagonists, used for the prevention and treatment of nausea and vomiting, particularly that caused by chemotherapy, radiation therapy, or postoperatively. The use of Palonosetron, compared with traditional 5-HT3 Ra’s, can be more effective in preventing chemotherapy-induced nausea and vomiting (CINV) during the first 24 hours following chemotherapy, which is the leading cause of premature discontinuation of chemotherapy. Palonosetron has the longest elimination half-life in its class of drug, after administration.